A Healthy Lifestyle may Offset Genetic Risk for Alzheimer’s

07/17/2019 03:00 | 58

A Healthy Lifestyle may Offset Genetic Risk for Alzheimer’s

A healthy lifestyle reduced dementia incidence in people with high-risk genetics, an analysis of almost 200,000 older adults in the UK Biobank showed.

In another research conducted by Dr Klodian Dhana at Rush University Medical Center in Chicago, 2,500 people were studied for around 10 years and several aspects of their lifestyle were monitored.

Though individuals can't change their genetic risk, they can modify their lifestyle and ultimately have a profound effect on whether they develop Alzheimer's, the team found. "Our findings are exciting as they show that although we can't change our genes, we can live a healthy lifestyle to try to reduce our risk of dementia".

"While this well-conducted study adds to data suggesting that a healthy lifestyle can help prevent dementia in many people, it is important to remember that some people will develop dementia no matter how healthy their lifestyle", Tara Spires-Jones, UK Dementia Research Institute programme lead, told Science Media Centre. "Spend more time being mindful of living a healthy life".

Most cases of dementia occur sporadically, in older people with multiple genetic risk factors. Studies have combined lifestyle factors to create a composite lifestyle score to investigate the relationship between lifestyle factors and other health conditions, such as cardiovascular disease and diabetes.

Their diet, their exercise regimen, whether or not they smoked, their alcohol consumption and their "engagement in cognitive stimulation activities", Dhana said.

Individuals who ate a "high-quality diet" of mostly vegetables, nuts, berries, beans, whole grains, seafood, poultry and olive oil - while avoiding red meats, butter, cheese, pastries, candies and fried food - earned 1s. Now researchers have shown the same to be true for dementia. After about eight years of examine, 1.8% of these with excessive genetic danger and poor lifestyles had developed dementia versus 0.6% of parents with low genetic danger and healthy habits. The results did not vary by race or gender, Dhana said. The researchers employed the help of the UK Biobank, which offered the profiles of 200,000 at or above the age of 60, which were healthy. The population studied included both men and women and blacks and non-Hispanic whites. The global cost of dementia in 2018 was roughly $1 trillion, a figure projected to double by 2030.

Maintaining a healthy lifestyle comes with various health benefits.

Old people in Sicily. "Also, walk to the grocery store and read books!"

It also sheds light on the belief that everyone with dementia was passed down their genes and is 100 percent set on developing the disease.

It was observed that people with high genetic risk and an unhealthy lifestyle were nearly three times more likely to develop dementia, in comparison to their counterparts with low genetic risk and favourable lifestyle. "If your circulatory and lymphatic systems are working, they'll do a better job of cleaning out the bad stuff", Haaga said.


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